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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: May 20, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Bone Health for Gynaecologists.

Angel Yordanov1, Mariela Vasileva-Slaveva2,3, Eva Tsoneva4

  • 1Department of Gynecologic Oncology, Medical University-Pleven, 5800 Pleven, Bulgaria.

Medicina (Kaunas, Lithuania)
|March 27, 2025
PubMed
Summary

This review highlights how physiological changes, diseases, and medications impact women's bone mineral density (BMD), increasing osteoporosis risk. Gynaecologists play a key role in preventing, diagnosing, and managing this common bone disorder.

Keywords:
bone healthdiagnosisgynaecologistosteoporosisrisk factors

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Area of Science:

  • Women's Health
  • Endocrinology
  • Gerontology

Background:

  • Osteoporosis is a prevalent bone disorder significantly affecting women, particularly postmenopause.
  • Diminished bone mineral density (BMD) leads to increased fracture risk, impacting quality of life and mortality.
  • Understanding factors contributing to bone loss is crucial for effective management.

Purpose of the Study:

  • To analyze the interplay of physiological changes, diseases, and medications causing reduced BMD in women.
  • To emphasize the critical role of gynaecologists in osteoporosis prevention, diagnosis, and management.
  • To review diagnostic tools and therapeutic strategies for preserving bone health.

Main Methods:

  • Comprehensive literature review analyzing physiological, pathological, and pharmacological factors influencing BMD.
  • Evaluation of diagnostic modalities including DXA, trabecular bone score, and quantitative ultrasonography.
  • Assessment of preventive and therapeutic interventions such as lifestyle modifications, HRT, SERMs, and anti-resorptive drugs.

Main Results:

  • Identified key risk factors including premature menopause, hormone deficits, and cancer therapies.
  • Highlighted the diagnostic utility of DXA and emerging techniques for precise bone health assessment.
  • Confirmed the efficacy of nutritional, exercise, and pharmacological interventions in managing osteoporosis.

Conclusions:

  • Gynaecologists are pivotal in proactive osteoporosis management through early risk assessment and tailored treatment.
  • A multidisciplinary approach integrating diagnostics and therapeutics is essential for improving long-term bone health outcomes in women.
  • Early intervention and lifestyle modifications are key to averting osteoporosis-related complications.