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Related Concept Videos

Extracellular Matrix01:26

Extracellular Matrix

2.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The Extracellular Matrix01:29

The Extracellular Matrix

8.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

6.9K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.3K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Updated: May 20, 2025

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

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Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics.

Morten Karsdal1, Thomas R Cox2,3, Amelia L Parker2,3

  • 1Nordic Bioscience, 2730 Herlev, Denmark.

Journal of Clinical Medicine
|March 27, 2025
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Summary

The extracellular matrix (ECM) is key in over 50 chronic diseases. Modulating ECM composition offers therapeutic potential for organ diseases, driving new drug development strategies.

Keywords:
chronic diseasesdrug developmentextracellular matrixliver diseasepharmacology congresssolid tumors

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Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
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Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
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A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
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Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
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Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
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Area of Science:

  • Biomedical Science
  • Pharmacology
  • Pathology

Background:

  • The extracellular matrix (ECM) is implicated in over 50 chronic diseases, exhibiting diverse effects like tissue formation, degradation, or both.
  • Pathologies affecting organs such as the lung, liver, kidney, skin, intestine, heart, and solid tumors involve significant ECM alterations.
  • Understanding the common and distinct features of the fibroinflammatory axis in ECM is crucial for cross-disease therapeutic strategies.

Purpose of the Study:

  • To explore the role of the extracellular matrix (ECM) in various chronic organ diseases.
  • To identify common denominators and distinguishing factors in ECM's fibroinflammatory axis for drug development.
  • To highlight advancements in tools and technologies for ECM-targeted drug discovery.

Main Methods:

  • Review of state-of-the-art research presented at the 2nd Extracellular Matrix Pharmacology Congress.
  • Discussion of ECM's role in liver, kidney, skin, intestine, musculoskeletal, lung, and solid tumor diseases.
  • Identification of key ECM targets and enabling technologies for therapeutic development.

Main Results:

  • The ECM is a central factor in numerous chronic pathologies, with common and unique fibroinflammatory characteristics across organs.
  • Effective therapies for organ diseases require modulation of ECM composition to restore normal function.
  • Advances in tools and technology are supporting the development of ECM-targeted drugs.

Conclusions:

  • Modulating the extracellular matrix (ECM) presents a promising avenue for treating a wide range of chronic organ diseases.
  • The 2nd Extracellular Matrix Pharmacology Congress facilitated knowledge exchange on ECM's role in disease and drug development.
  • Further research into ECM targets and technologies is essential for advancing therapeutic interventions.