Use of Pranoprofen After Strabismus Surgery in Children

Area of Science:

• Ophthalmology
• Pediatric Surgery
• Pharmacology

Background:

• Postoperative ocular inflammation and complications are common after strabismus surgery in children.
• Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to manage postoperative inflammation.

Purpose of the Study:

• To evaluate the efficacy of pranoprofen 0.1% in preventing postoperative complications, specifically ocular inflammation, following pediatric strabismus surgery.
• To compare the safety and efficacy of pranoprofen with dexamethasone in postoperative eye care.

Main Methods:

• A prospective study involving 90 children (ages 2-17) undergoing strabismus surgery.
• Patients were randomized into three groups receiving different topical postoperative treatments including tobramycin, pranoprofen, dexpanthenol, and/or dexamethasone.
• Follow-up assessments were conducted post-surgery on day 14, and at 3 months.

Main Results:

• No postoperative infections were observed in any group.
• Group II (dexamethasone) exhibited a statistically significant higher rate of complications (allergic reactions, delle, granuloma) compared to groups I and III (p=0.032).
• Allergic reactions occurred in one patient each in groups I and III.

Conclusions:

• Postoperative pranoprofen is as effective as glucocorticosteroids in managing ocular inflammation after strabismus surgery.
• Pranoprofen appears to have a favorable safety profile with fewer complications, especially for extended anti-inflammatory treatment.
• Regular postoperative monitoring is crucial for early detection and management of potential complications.