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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

109
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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270
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
270

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Updated: May 20, 2025

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Ciprofloxacin-Loaded Spray-Dried Lactose Particles: Formulation Optimization and Antibacterial Efficacy.

Sai Liu1, Simon Gaisford1, Gareth R Williams1

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

Pharmaceutics
|March 27, 2025
PubMed
Summary

Spray-dried lactose microparticles loaded with ciprofloxacin (cipro) show promise for treating bacterial infections. These antibiotic particles effectively target oral and outer ear infections, demonstrating rapid drug release and potent antibacterial activity.

Keywords:
antimicrobialciprofloxacinparticlespray drying

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Bacterial infections in the oral cavity and outer ear necessitate advanced drug delivery systems.
  • Targeted antibiotic formulations are crucial for combating localized infections.

Purpose of the Study:

  • To develop and characterize drug-loaded lactose microparticles for antibiotic delivery.
  • To create effective formulations for treating oral and outer ear bacterial infections.

Main Methods:

  • Lactose microparticles were produced using spray drying.
  • Particles were optimized for ciprofloxacin loading and characterized for physicochemical properties, drug release, and antibacterial efficacy.

Main Results:

  • Spherical lactose microparticles achieved high ciprofloxacin loading (1.1-52.9% w/w).
  • Rapid drug release (70-81% in 5 h) and concentration-dependent antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were observed.
  • Bacterial growth was inhibited for over 24 hours at minimum inhibitory concentrations.

Conclusions:

  • Spray-dried ciprofloxacin-loaded lactose microparticles offer an efficient localized antibacterial treatment strategy.
  • These particles present a promising solution for managing bacterial infections in the oral cavity and outer ear.