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Nanosponge-Encapsulated Polyoxometalates: Unveiling the Multi-Faceted Potential Against Cancers and Metastases
Muhammad Sajjad1, Muhammad Zubair Malik1, Ayesha Bint Umar Awan2
1Faculty of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Pharmaceuticals (Basel, Switzerland)
|March 27, 2025
Summary
New nanosponges loaded with polyoxometalates (TiW11Co) show enhanced anticancer effects. These targeted nanosponges improved tumor reduction and survival rates in mice, offering potential for novel cancer therapies.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Development of novel drug delivery systems for targeted cancer therapy.
- Polyoxometalates (TiW11Co) show promise but require effective delivery mechanisms.
- Nanosponges (NS) offer a versatile platform for encapsulating therapeutic agents.
Purpose of the Study:
- To fabricate and characterize nanosponges (NS) loaded with polyoxometalates (TiW11Co) for targeted malignancy treatment.
- To evaluate the in vitro and in vivo efficacy of TiW11Co-loaded nanosponges (TiW11Co-NS).
Main Methods:
- Fabrication of TiW11Co-NS using the emulsion solvent diffusion technique with polyvinyl alcohol (PVA) and ethyl cellulose (EC).
- Characterization using dynamic light scattering (DLS), zeta potential measurements, and electron microscopy (SEM, TEM).
- In vitro evaluation including enzyme inhibition (TNAP), cytotoxicity, and apoptosis assays.
- In vivo studies in mice assessing tumor weight reduction and survival rates.
- Molecular docking to predict interactions with cancer-related proteins.
Main Results:
- TiW11Co-NS exhibited optimal particle size (109.5 nm), high loading efficiency (85.9%), and good stability.
- TiW11Co-NS demonstrated enhanced cytotoxicity, apoptosis induction, and superior inhibition of TNAP compared to free TiW11Co.
- In vivo studies showed significant tumor weight reduction and increased survival rates in mice treated with TiW11Co-NS.
- Molecular docking supported the therapeutic potential of TiW11Co by predicting binding to crucial cancer proliferation proteins.
Conclusions:
- TiW11Co-laden nanosponges represent a promising nanocarrier system for targeted cancer therapy.
- The developed TiW11Co-NS exhibit enhanced stability, enzyme inhibition, cytotoxicity, and in vivo anticancer efficacy.
- These findings underscore the potential of TiW11Co-NS as an effective strategy against malignancy.
