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Pediatric functional lung imaging and pulmonary function testing: a scoping review protocol
Matthew Bruorton1,2, Sarah Greenslade1,2, Shagufta Perveen2,3
1Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.
Insights
This review identifies functional lung imaging techniques used in children and compares them to pulmonary function tests. It highlights emerging technologies for better pediatric lung disease assessment.
Area of Science:
- Medical Imaging
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- Functional lung imaging non-invasively maps ventilation, perfusion, gas exchange, and biomechanics.
- It offers regional insights into lung disease beyond traditional pulmonary function tests.
- These techniques hold significant potential for managing pediatric lung conditions.
Purpose of the Study:
- To identify current and emerging functional lung imaging techniques in pediatric cohorts.
- To determine how these techniques compare with established pulmonary function tests.
Main Methods:
- Scoping review of quantitative studies and conference abstracts comparing functional lung imaging with pulmonary function tests in children.
- Inclusion of gray literature and expert opinion for novel technologies.
- Systematic search of MEDLINE, Embase, and CINAHL databases.
Main Results:
- Data extraction on study concepts, contexts, and methods.
- Presentation of findings in tabular format with narrative synthesis.
- Identification of techniques and their comparative performance against pulmonary function tests.
Conclusions:
- Functional lung imaging provides valuable spatial and regional data for pediatric lung disease.
- Further research into emerging techniques can enhance clinical management.
- This review synthesizes current knowledge and identifies future directions in pediatric functional lung imaging.
Objective:
This scoping review aims to identify current and emerging functional lung imaging techniques that have been used in pediatric cohorts and how these techniques have been compared to pulmonary function tests.
Introduction:
Functional lung imaging enables the assessment of distribution of pulmonary parameters-including ventilation, perfusion, gas exchange, and biomechanics-to be mapped and quantified non-invasively throughout the lungs. In comparison to pulmonary function testing, functional lung imaging can provide additional clinically relevant information on the regional and spatial localization of lung disease. Pulmonary functional imaging has the potential to significantly benefit a pediatric cohort, giving clinicians an additional tool in assessing and managing pediatric lung disease.
Eligibility Criteria:
Functional lung imaging techniques that have been investigated and compared or correlated with a pulmonary function test in pediatric cohorts will be identified and reviewed. Quantitative study designs and functional lung imaging techniques used in reviews and conference abstracts will be included if there is a comparative pulmonary function test. Gray literature will be screened for evidence of new and emerging technologies. Established author opinion will also be sought on new and emerging technologies in pediatric functional lung imaging.
Methods:
Key sources to be searched include MEDLINE, Embase, and CINAHL. Two reviewers will independently screen titles and abstracts against eligibility criteria. Extracted data will include details about the concept, context, study methods, and key information relevant to the study question. Data will be presented in tabular format, accompanied by a narrative synthesis.
Review Registration:
OSF https://osf.io/snuc6.
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