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Chronic Eosinophilic Leukemia Positive for FIP1L1-PDGFRa
Steven J Haydon1,2, Danielle E Ross1,2, Stephen Caucci1,2
1Internal Medicine, Mclaren Greater Lansing, Lansing, USA.
Cureus
|March 27, 2025
Summary
FIP1L1-PDGFRα-positive chronic eosinophilic leukemia (CEL) is a rare cancer. Treatment with imatinib and prednisone effectively reduced eosinophil counts and induced remission in a 71-year-old male patient.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chronic eosinophilic leukemia (CEL) is a rare myeloproliferative neoplasm.
- FIP1L1-PDGFRα rearrangement defines a specific subtype of CEL.
- Eosinophilic granules release cytokines (IL-5, IL-4, IL-13) causing organ damage.

