Related Experiment Video
Updated: May 20, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
First demonstration of implication of hereditary alpha-tryptasaemia in vasospastic angina: a case report
Benoit Caullery1, Alexis Bocquet2, Laurent Riou3
1Department of Cardiology, University Hospital, Grenoble 38000, France.
Background:
Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored.
Case Summary:
A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease.
Discussion:
The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.
Related Concept Videos
Adrenergic Receptors: ɑ Subtype
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Vascular Spasm
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
X-linked Traits

