Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lactate infusions in obsessive-compulsive disorder.

J M Gorman, M R Liebowitz, A J Fyer

    The American Journal of Psychiatry
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lipid emulsion infusion and its effect on anaesthetic drugs.

    Anaesthesia reports·2026
    Same author

    Variation in faecal testosterone levels in male gray whales on a foraging ground relative to maturity and timing.

    Conservation physiology·2025
    Same author

    Assessment of a non-invasive approach to pregnancy diagnosis in gray whales through drone-based photogrammetry and faecal hormone analysis.

    Royal Society open science·2023
    Same author

    Evaluating Dermal Bone as a Novel Source of Endocrine Information in Ninespine and Threespine Stickleback Fish.

    Integrative organismal biology (Oxford, England)·2023
    Same author

    PACK syndrome: A case series and review.

    The American journal of the medical sciences·2022
    Same author

    An experimental aerosol air-agar interface mouse lymphoma assay methodology.

    Mutation research. Genetic toxicology and environmental mutagenesis·2020

    Sodium lactate infusions triggered panic attacks in patients with panic disorder or agoraphobia, but not typically in those with obsessive-compulsive disorder. This indicates lactate-induced panic is specific to panic disorder.

    Area of Science:

    • Psychiatry
    • Neuroscience
    • Clinical Psychology

    Background:

    • Panic attacks are a core feature of several psychiatric disorders.
    • Sodium lactate infusions are known to provoke panic attacks in susceptible individuals.

    Purpose of the Study:

    • To investigate the specificity of lactate-induced panic attacks across different patient groups.
    • To differentiate the physiological responses to sodium lactate in obsessive-compulsive disorder versus panic disorder.

    Main Methods:

    • Administered intravenous sodium lactate infusions to patients diagnosed with obsessive-compulsive disorder (OCD).
    • Administered intravenous sodium lactate infusions to patients diagnosed with panic disorder or agoraphobia with panic attacks.
    • Monitored and recorded patient responses, specifically the occurrence of panic attacks.

    Related Experiment Videos

    Main Results:

    • One out of seven patients with obsessive-compulsive disorder experienced panic attacks following sodium lactate infusion.
    • Twenty-six out of 48 patients with panic disorder or agoraphobia with panic attacks experienced panic attacks.
    • A significantly higher incidence of panic attacks was observed in patients with panic disorder/agoraphobia compared to OCD patients.

    Conclusions:

    • Lactate-induced panic attacks appear to be a specific physiological response associated with panic disorder and agoraphobia.
    • The findings suggest distinct neurobiological mechanisms underlying panic attacks in obsessive-compulsive disorder and panic disorder.
    • Sodium lactate challenge may serve as a useful diagnostic or research tool for differentiating these conditions.