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RETRACTION: DUSP1 Recuses Diabetic Nephropathy via Repressing JNK-Mff-Mitochondrial Fission Pathways
Insights
This study investigated the role of DUSP1 in diabetic nephropathy, a kidney disease associated with diabetes. The findings suggested a potential therapeutic pathway involving mitochondrial dynamics.
Area of Science:
- Cellular Physiology
- Renal Pathophysiology
- Mitochondrial Biology
Background:
- Diabetic nephropathy is a significant complication of diabetes mellitus, leading to kidney damage.
- Mitochondrial dysfunction and altered mitochondrial dynamics, including fission and fusion, are implicated in the pathogenesis of diabetic nephropathy.
- Dual-specificity phosphatase 1 (DUSP1) is a key regulator of cellular stress responses.
Purpose of the Study:
- To investigate the role of DUSP1 in the development and progression of diabetic nephropathy.
- To elucidate the molecular mechanisms by which DUSP1 influences kidney injury in diabetes, focusing on mitochondrial fission pathways.
Main Methods:
- The study utilized cellular and animal models of diabetic nephropathy.
- Investigated the expression and function of DUSP1 in kidney tissues.
- Analyzed the impact of DUSP1 on the JNK-Mitochondrial Fission Factor (Mff) pathway and mitochondrial fission.
Main Results:
- DUSP1 was found to be downregulated in diabetic nephropathy.
- Overexpression of DUSP1 ameliorated kidney injury in diabetic models.
- DUSP1 was shown to repress the JNK-Mitochondrial Fission Factor (Mff) pathway, thereby inhibiting excessive mitochondrial fission.
Conclusions:
- DUSP1 plays a protective role in diabetic nephropathy by modulating mitochondrial dynamics.
- Targeting the DUSP1-JNK-Mff-mitochondrial fission axis may represent a novel therapeutic strategy for diabetic kidney disease.
Retraction:
Sheng, J., H. Li, Q. Dai, C. Lu, M. Xu, J. Zhang, and J. Feng, "DUSP1 Recuses Diabetic Nephropathy via Repressing JNK-Mff-Mitochondrial Fission Pathways." Journal of Cellular Physiology 234, no. 3 (2019): 3043-3057. https://doi.org/10.1002/jcp.27124. The above article, published online on September 7, 2018, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath, and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Several irregularities were found, including, but not limited to, multiple image elements being published in later articles by different author groups and in distinct scientific contexts, indicating inappropriate data sharing. The authors were invited to comment on these concerns but did not respond. Further investigation by the publisher revealed that the article was accepted solely on the basis of a compromised peer review process. Accordingly, the article is retracted as the editors have lost confidence in the integrity and reliability of the full body of data presented in the article and consider its conclusions invalid. The authors were informed of the retraction.
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