Related Experiment Video
Updated: Jun 15, 2026
06:24
Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling
Published on: July 26, 2024
1.1K
Exploring organoid and assembloid technologies: a focus on retina and brain.
Sara Ouaidat1, Alessandro Bellapianta1, Franziska Ammer-Pickhardt1,2
1Research Group Cellular and Molecular Ophthalmology, University Clinic for Ophthalmology and Optometry, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria.
Expert Reviews in Molecular Medicine
|March 27, 2025
Summary
Organoid technology advances in vitro disease modeling, with retinal and brain organoids showing promise as alternatives to transplants. Emerging assembloid models address current organoid limitations for better disease understanding.
Area of Science:
- Biomedical Engineering
- Developmental Biology
- Regenerative Medicine
Background:
- Three-dimensional organoids are crucial in vitro disease models, revealing organ-specific complexities.
- Challenges with current organoids drive the development of advanced assembloid structures.
Purpose of the Study:
- To review distinct organoid types, focusing on retinal and brain organoids for disease modeling.
- To explore organoids as alternatives to organ/cell transplantation.
Main Methods:
- Review of published research on organoid applications.
- Discussion of photostimulation in retinal organoids.
- Exploration of microfluidics and organ-on-a-chip technologies.
Main Results:
- Retinal and brain organoids show potential as alternatives to transplantation.
- Photostimulation and microfluidic integration enhance retinal organoid function.
- Organoid challenges led to the development of assembloid fusion models.
Conclusions:
- Organoid technology provides superior in vitro models that mimic in vivo systems.
- These advanced models deepen the understanding of disease pathophysiology.
