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KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus

Yanming Hu1, Jing Zhou2, Xinru Ling3

  • 1Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Suzhou, China.

Cancer Medicine
|March 27, 2025
PubMed
Abstract

Insights

KPNA5 acts as a tumor suppressor in ovarian cancer (OC) by regulating protein transport. Downregulation of KPNA5 is linked to poor survival, while its restoration inhibits OC cell growth and invasion.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Disrupted nucleoplasmic transport affects tumor cells, but mechanisms are unclear.
  • Karyopherin proteins are crucial for nuclear transport and cellular processes.
  • The role of karyopherins in ovarian cancer (OC) is not well understood.

Purpose of the Study:

  • To investigate the role of KPNA5 in ovarian cancer (OC).
  • To determine if KPNA5 functions as a tumor suppressor in OC.

Main Methods:

  • Detected KPNA5 expression using IHC, Western blot, and qPCR.
  • Assessed OC cell proliferation, migration, and invasion in vitro.
  • Evaluated KPNA5's effect on tumor growth in a xenograft model.

Main Results:

  • KPNA5 expression was downregulated in OC tissues and associated with poor patient survival.
  • KPNA5 overexpression suppressed OC cell proliferation, tumor growth, and invasion.
  • KPNA5 mediated nuclear transport of PTPN4, inhibiting STAT3 phosphorylation.

Conclusions:

  • KPNA5 functions as a tumor suppressor in ovarian cancer (OC).
  • KPNA5 represents a potential therapeutic target for OC treatment.
Keywords:
KPNA5PTPN4STAT3ovarian cancertumor suppressor

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