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Biological Fluid Flows: Signaling Mediums for Circadian Timing
Evalien Duyvesteyn1, Velia S Vizcarra1, Emma Waight1
1Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA.
Journal of Biological Rhythms
|March 27, 2025
Summary
Interstitial fluid (ISF) signaling is crucial for circadian synchronization. Fluid movement between the brain and body, particularly via the glymphatic and lymphatic systems, acts as a key timing mechanism for biological rhythms.
Area of Science:
- Neuroscience
- Chronobiology
- Physiology
Background:
- Extensive research exists on neuronal rhythms and intracellular molecular clocks.
- Interstital fluid (ISF) signaling, the fluid surrounding cells, remains understudied in circadian biology.
- ISF acts as a critical communication medium within tissues.
Purpose of the Study:
- To review evidence supporting ISF signaling in circadian synchronization and entrainment.
- To propose mechanisms for how ISF dynamics influence biological rhythms.
- To examine the role of the glymphatic and lymphatic systems in circadian regulation.
Main Methods:
- Review of existing circadian literature.
- Analysis of ISF and cerebrospinal fluid (CSF) production.
- Examination of glymphatic and lymphatic system structures and functions.
Main Results:
- ISF plays a significant role in synchronizing circadian rhythms.
- Fluid exchange pathways, including the glymphatic and lymphatic systems, are integral to circadian timing.
- Circadian regulation impacts the function of these fluid systems.
Conclusions:
- ISF is a vital, yet underappreciated, component of the circadian timing system.
- Understanding ISF dynamics offers new insights into how the brain and periphery synchronize biological clocks.
- The glymphatic and lymphatic systems are key players in mediating circadian timing signals throughout the body.
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