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Association between the triglyceride-glucose index in third trimester pregnant women and neonatal birth weight

Jialei Shen1, Wenhui Liu2, Kedan Cao3

  • 1Department of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou, China. sjlfish@163.com.

Ginekologia Polska
|March 27, 2025
PubMed

Insights

The triglyceride-glucose (TYG) index in late pregnancy positively correlates with neonatal birth weight. Higher TYG index values are linked to increased infant weight, suggesting its potential as a predictive marker.

Area of Science:

  • Reproductive Medicine
  • Metabolic Health
  • Neonatal Development

Background:

  • Neonatal birth weight is critical for infant health and development.
  • The triglyceride-glucose (TYG) index reflects maternal insulin resistance and metabolic status.
  • Maternal metabolic health significantly influences fetal growth.

Purpose of the Study:

  • To investigate the association between the maternal triglyceride-glucose (TYG) index in the third trimester and neonatal birth weight.
  • To determine if the TYG index can serve as a predictive biomarker for fetal growth.

Main Methods:

  • A cohort of 475 neonates and their mothers was studied.
  • Maternal TYG index was calculated in the third trimester.
  • Correlation and multivariate regression analyses were used to assess the association with neonatal birth weight.

Main Results:

  • A significant positive correlation was found between the TYG index and neonatal birth weight (r=0.314, p<0.001).
  • Each increment in TYG index was associated with a 227.22g increase in neonatal weight.
  • The association was stronger in mothers without gestational diabetes, in male neonates, and in mothers over 31.

Conclusions:

  • The TYG index in the third trimester is a significant positive predictor of neonatal birth weight.
  • The TYG index may be a valuable tool for predicting fetal growth and managing pregnancy.
  • Stronger associations in specific subgroups highlight potential targeted applications.
Abstract

Keywords:
gestational diabetes mellitusinsulin resistanceneonatal birth weighttriglyceride-glucose index

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