Related Experiment Video
Updated: May 20, 2025
12:37
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
Published on: September 11, 2012
46.7K
Isolated colonic amyloidosis: a rare condition mimicking malignancy.
Macarena Torres-Larrubia1, Sergio Casiano-Manzano1, Zulianni Andreina Jiménez-Colmenárez1
1Gastroenterology, Complejo Hospitalario Universitario de Cáceres, España.
Revista Espanola De Enfermedades Digestivas
|March 27, 2025
Summary
This case study details a 54-year-old male with localized colonic amyloidosis, initially presenting as rectal bleeding. Diagnosis required histopathology to differentiate from neoplastic lesions and rule out systemic amyloidosis.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Amyloidosis is a rare condition characterized by the deposition of amyloid proteins in various organs.
- Colonic amyloidosis can present atypically, mimicking neoplastic lesions, leading to diagnostic challenges.
- Distinguishing between localized and systemic forms is crucial for patient management.
Related Concept Videos
03:03Amyloid Fibrils
9.1K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.1K
01:30Inflammatory Bowel Disease II: Crohn's Disease
141
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
141
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
103
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
103