LncRNA regulation in ischemic stroke and their application prospects.
Qianqian Chen1, Xiangyi Xu1, Shun Li2
1Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Neural Regeneration Research
|March 27, 2025
Summary
Long non-coding RNAs (lncRNAs) show promise in understanding and treating ischemic stroke by regulating gene expression. Further research is needed to overcome challenges for clinical application.
Area of Science:
- Molecular Biology
- Genetics
- Neurology
Background:
- Ischemic stroke has profound, lasting impacts.
- Understanding molecular mechanisms, including gene expression, is crucial.
- Regulatory long non-coding RNAs (lncRNAs) are a key research area in cerebral infarction.
Purpose of the Study:
- To comprehensively review the roles of regulatory lncRNAs in ischemic stroke.
- To explore potential clinical applications of lncRNAs in treating cerebral infarction.
- To identify specific lncRNAs involved in stroke pathology and treatment.
Main Methods:
- Literature review of studies on lncRNAs in ischemic stroke.
- Analysis of lncRNA interactions with microRNAs (miRNAs).
- Examination of lncRNAs used in animal models and as biomarkers.
Main Results:
- LncRNAs act as miRNA sponges, regulating target gene expression.
- Specific lncRNAs (e.g., NKILA, Meg8, H19) show therapeutic potential in animal models.
- LncRNAs (e.g., FOXO3, XIST, RMST) are investigated as diagnostic and prognostic biomarkers.
Conclusions:
- Regulatory lncRNAs play significant roles in ischemic stroke processes like reperfusion injury, cell death, and angiogenesis.
- LncRNAs offer potential for genetic-level stroke treatments.
- Clinical application faces challenges including efficiency, targeting accuracy, and side effects requiring further validation.
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