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Disturbances of Dental Development in Cleidocranial Dysplasia
Vincent R The1, Brunilda Dhamo1,2, Eppo B Wolvius1,2
1Department of Oral & Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Centre.
Objective:
This study aimed to investigate the delay in dental development in patients with cleidocranial dysplasia (CCD) applying a longitudinal approach of maturational stages of teeth. A secondary objective was to examine whether an increasing number of supernumerary teeth influences dental development.
Methods:
A total of 38 patients were included, consisting of 13 patients with CCD and 25 without CCD, selected from the Generation R Study. Both groups were matched by age and number of supernumerary teeth.Dental development was assessed using the Demirjian method. Linear mixed models were used to study the longitudinal aspects of dental development delay between the 2 timepoints. Subgroup analysis was performed using 3 linear regression models to study the extent of dental development delay in CCD patients compared with the control group and to evaluate the influence of an increasing number of supernumerary teeth on developmental delay.
Results:
No significant decelerations in dental development between late childhood and early adolescence were found in both groups. However, the CCD group showed a delay in dental development of 3.3 years [β -0.8; 95% CI (-4.3,-2.2)] in comparison to the control group when confounded for sex and supernumerary teeth. The number of supernumery teeth proved not to be a significant determinant as there was a P -value of 0.22.
Conclusions:
The authors' findings indicate that dental development in CCD patients is delayed by ~3.3 years, which stays stable from adolescence. An increasing number of supernumerary teeth did not contribute to further delays in dental development.
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