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Published on: October 12, 2017
High-Density Lipoprotein Cholesterol Trajectories and Lung Function Decline: A Prospective Cohort Study.
Byunghun Yoo1, Sun Ho Jung2, Soo Han Bae1,3
1Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, South Korea.
Lung
|March 27, 2025
Summary
Low high-density lipoprotein cholesterol (HDL-C) levels are linked to faster lung function decline over time. This study highlights the importance of maintaining adequate HDL-C for pulmonary health.
Area of Science:
- Pulmonary Medicine
- Cardiovascular Health
- Epidemiology
Background:
- Cholesterol regulation is crucial for maintaining pulmonary homeostasis.
- Higher high-density lipoprotein cholesterol (HDL-C) levels are associated with better lung function.
- The longitudinal relationship between HDL-C and lung function decline is not well understood.
Purpose of the Study:
- To investigate the long-term association between HDL-C levels and lung function decline.
- To analyze the correlation of different HDL-C trajectories with changes in lung function over time.
Main Methods:
- A prospective, population-based cohort study in South Korea included 7,652 participants.
- Participants were grouped into five trajectories based on repeated HDL-C measurements.
- Generalized linear mixed models were used to assess the longitudinal relationship between HDL-C and lung function (FVC, FEV1).
Main Results:
- The very low HDL-C trajectory group showed the fastest decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) (-3.1 mL/year for both).
- The low HDL-C trajectory group also exhibited faster declines in FVC (-1.5 mL/year) and FEV1 (-1.7 mL/year) compared to the reference group.
- These findings were consistent across different numbers of HDL-C trajectory groups.
Conclusions:
- Lower HDL-C trajectory groups are associated with a more rapid decline in lung function over time.
- This suggests a negative longitudinal association between HDL-C levels and lung function decline.
- Maintaining adequate HDL-C may be important for preserving lung function in the long term.
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