Identification of tumor immune infiltration-associated VPS72 and prognostic significance of VPS72 and CD8A in hepatocellular carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.VPS72 expression in hepatocellular carcinoma (HCC) correlates with immune cell infiltration. Low VPS72 and high CD8A coexpression indicate a favorable prognosis, suggesting their use as biomarkers for HCC immune response.
Area Of Science
- Oncology
- Immunology
- Genetics
Background
- Copy Number Alterations (CNAs) are key drivers in cancer immunotherapy.
- VPS72 is a potential marker for predicting response to immune checkpoint blockade in hepatocellular carcinoma (HCC).
- The precise role of VPS72 in immune infiltration within HCC remains largely unknown.
Purpose Of The Study
- To investigate the association between VPS72 expression and immune infiltration in HCC.
- To explore VPS72 as a potential prognostic biomarker in HCC.
Main Methods
- Utilized TIMER analysis on bulk-RNAseq data to assess immune cell populations.
- Analyzed data from TCGA, GEO databases, clinical specimens, and animal models.
- Performed differential expression and KEGG pathway analysis.
Main Results
- VPS72 was significantly enriched among immune-related genes (IRGs) in altered groups.
- Low VPS72 expression correlated with high CD8+ T cell infiltration in HCC datasets.
- VPS72-knockdown tumors and patient cohorts showed increased CD8A expression.
- A subtype with low VPS72 and high CD8A expression demonstrated improved disease-free survival.
Conclusions
- VPS72 expression is linked to tumor immune infiltration in HCC.
- Coexpression of VPS72 and CD8A serves as a prognostic biomarker for HCC.
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