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Updated: Jun 16, 2025

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The critical role of X-linked inhibitor of apoptosis protein (XIAP) in tumor development

Hui Fan1, Jiyuan Liu1, Xiangyan Hu1

  • 1Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Apoptosis : an International Journal on Programmed Cell Death
|March 27, 2025
PubMed

Insights

X-linked inhibitor of apoptosis protein (XIAP) is a key regulator of cell death pathways. Its role in cancer progression makes XIAP a promising therapeutic target for novel anti-cancer drugs.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • X-linked inhibitor of apoptosis protein (XIAP) is a potent endogenous inhibitor of apoptosis.
  • XIAP regulates both the death receptor and mitochondrial apoptosis pathways.
  • XIAP's involvement in tumor development highlights its significance in cancer biology.

Purpose of the Study:

  • To review the structural characteristics and biological functions of XIAP.
  • To elucidate the role of XIAP in tumor development and progression.
  • To provide an overview of XIAP-targeted inhibitors for cancer therapy.

Main Methods:

  • Literature review of XIAP's structure and function.
  • Analysis of XIAP's involvement in apoptosis pathways.
  • Compilation of data on XIAP's role in various cancers.
  • Survey of current XIAP-targeted therapeutic strategies.

Main Results:

  • XIAP directly binds caspases and activates NF-κB signaling.
  • XIAP's anti-apoptotic functions promote tumor cell survival and progression.
  • Multiple XIAP-targeted inhibitors are under investigation for cancer treatment.

Conclusions:

  • XIAP is a critical regulator of apoptosis with significant implications in cancer.
  • Targeting XIAP presents a viable therapeutic strategy for various malignancies.
  • Further research into XIAP inhibitors may lead to novel cancer treatments.
Keywords:
ApoptoticTumorXIAPXIAP inhibitor

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