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Updated: May 6, 2026

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
Published on: December 22, 2017
IVCA in a Boy with Multilocular Renal Cyst as a Risk Factor for Deep Vein Thrombosis
Agnieszka Szmigielska1, Piotr Skrzypczyk1, Michał Szyszka1
1Department of Pediatrics and Nephrology, Medical University of Warsaw.
Insights
KILT syndrome involves kidney defects, congenital inferior vena cava agenesis (IVCA), and leg deep vein thrombosis. Early detection of IVCA is crucial for preventing dangerous thrombotic complications.
Area of Science:
- Vascular Surgery
- Nephrology
- Radiology
Background:
- KILT syndrome is characterized by renal defects, congenital inferior vena cava agenesis (IVCA), and lower limb deep vein thrombosis.
- Congenital IVCA is a rare vascular anomaly that can lead to significant clinical complications.
Introduction:
The triad of symptoms: renal defects, congenital inferior vena cava agenesis (IVCA) and deep vein thrombosis of the lower limbs make up the KILT syndrome (kidney and IVC abnormalities with leg thrombosis).
Case Report:
A 17-year-old boy complained of periodic abdominal pain. Abdominal ultrasonography revealed a multilocular cyst in the right kidney. Physical examination showed no abnormalities, and his blood pressure was 120/80mmHg. Abdominal ultrasonography showed a cyst measuring 36×30×25mm in the right kidney hilum. Computed tomography did not show the hepatic and suprarenal sections of the inferior vena cava. Numerous varicose-dilated collateral vessels, including renal venous vessels, were found in the right kidney hilum. The collateral vessels in the tomography matched the described in the ultrasound renal cyst. MRI confirmed IVCA with no other additional vascular abnormalities. Due to the risk of deep vein thrombosis of the lower limbs, non-pharmacological antithrombotic prophylaxis was recommended.
Conclusions:
Early detection of inferior vena cava agenesis allows for the reduction of the risk of dangerous thrombotic complications.
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