Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery: A VISION Substudy
- Ann Le 1, Guillaume Paré 2, P J Devereaux 3, Ibrahim Quazi 4, Shihong Mao 5, Michael Chong 6, Diane Heels-Ansdell 4, Emmanuelle Duceppe 7, Michael Ke Wang 8, Ameen Patel 9, Maria Tiboni 9, Patrick Magloire 9, Amit X Garg 10, Sandra N Ofori 3, David Conen 3, Jessica Spence 11, Emilie Belley-Côté 8, Caleb Beck 12, William F McIntyre 8, Richard Whitlock 5, Jeff S Healey 8, Shirley Pettit 5, Flavia K Borges 3,
- Ann Le 1, Guillaume Paré 2, P J Devereaux 3
- 1Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada.
- 2Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
- 3Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 4Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
- 5Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada.
- 6Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada.
- 7Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Centre hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Quebec, Canada.
- 8Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 9Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- 10Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Division of Nephrology, London Health Sciences Centre, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
- 11Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Department of Anesthesia and Critical Care, McMaster University, Hamilton, Ontario, Canada.
- 12Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Ecology and Evolution, University of Lausanne, Faculty of Biology and Medicine, Quartier Centre, Lausanne, Switzerland.
- 0Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada.
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View abstract on PubMed
Summary
This summary is machine-generated.Polygenic risk scores for type II diabetes and HbA1c levels are linked to myocardial injury after noncardiac surgery (MINS). Integrating these genetic factors may improve prediction of MINS, a common postsurgical complication.
Area Of Science
- Cardiology
- Genetics
- Perioperative Medicine
Background
- Myocardial injury after noncardiac surgery (MINS) is a frequent vascular complication.
- The revised cardiac risk index (RCRI) has suboptimal predictive accuracy for MINS.
- Genetic factors may enhance the prediction of MINS.
Purpose Of The Study
- To investigate the integration of polygenic risk scores (PRS) with RCRI for improved MINS prediction.
- To identify specific PRS associated with MINS and gain pathophysiological insights.
Main Methods
- A case-control study within the Vascular Events in Noncardiac Surgery Participants Cohort Evaluation.
- Inclusion of patients aged 45+ undergoing noncardiac surgery.
- Measurement of daily troponin levels and computation of PRS for MINS risk factors.
- Logistic regression models to assess PRS association with MINS, evaluated independently and with RCRI.
Main Results
- The study included 253 MINS cases and 253 controls of European ancestry.
- Polygenic risk scores for type II diabetes (T2D PRS) and HbA1c were significantly associated with MINS.
- No significant associations were found for PRS related to coronary artery disease, stroke, or lipid biomarkers.
Conclusions
- T2D PRS and HbA1c PRS are associated with an increased risk of MINS.
- These findings suggest the multifactorial pathophysiology of MINS.
- Further genetic studies and trials on perioperative glucose management are recommended.
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