Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association Between Complications and Death Within 30 Days After Orthopedic Surgery: Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy.

JMIR perioperative medicine·2026

Same author

ASSOCIATION BETWEEN COMPLICATIONS AND DEATH WITHIN 30 DAYS AFTER ORTHOPEDIC SURGERY: A VASCULAR EVENTS IN NONCARDIAC SURGERY PATIENTS COHORT EVALUATION (VISION) SUBSTUDY.

JMIR perioperative medicine·2026

Same author

Pain as a Driver of Myocardial Injury in Hip Fracture Patients: A Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Trial Secondary Analysis.

Anesthesiology·2025

Same author

Cemented Fixation in Arthroplasty for Hip Fractures Does Not Increase Cardiopulmonary Complications: A Secondary Analysis of the HIP ATTACK Trial.

Clinical orthopaedics and related research·2025

Same author

Frailty Assessment for Risk prediction in Gynecologic Oncology patients undergoing surgery and chemotherapy (FARGO) study protocol: Rationale and design of a multi-centre prospective cohort study.

PloS one·2025

Same author

Correction: "Impact of Virtual Care With Remote Automated Monitoring on the Rate of Acute Hospital Care Post Discharge and Index Length of Hospital Stay: Protocol for the Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology 3 (PVC-RAM-3) Trial".

Journal of medical Internet research·2025

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery: A VISION Substudy.

Ann Le¹, Guillaume Paré², P J Devereaux³

¹Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada.

|March 27, 2025

Summary

This summary is machine-generated.

Polygenic risk scores for type II diabetes and HbA1c levels are linked to myocardial injury after noncardiac surgery (MINS). Integrating these genetic factors may improve prediction of MINS, a common postsurgical complication.

Keywords:

VISION cardiovascular genetics myocardial injury after noncardiac surgery MINS polygenic risk scores revised cardiac risk index

More Related Videos

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jul 7, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease

Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease

Published on: September 20, 2024

Area of Science:

Cardiology
Genetics
Perioperative Medicine

Background:

Myocardial injury after noncardiac surgery (MINS) is a frequent vascular complication.
The revised cardiac risk index (RCRI) has suboptimal predictive accuracy for MINS.
Genetic factors may enhance the prediction of MINS.

Purpose of the Study:

To investigate the integration of polygenic risk scores (PRS) with RCRI for improved MINS prediction.
To identify specific PRS associated with MINS and gain pathophysiological insights.

Main Methods:

A case-control study within the Vascular Events in Noncardiac Surgery Participants Cohort Evaluation.
Inclusion of patients aged 45+ undergoing noncardiac surgery.
Measurement of daily troponin levels and computation of PRS for MINS risk factors.
Logistic regression models to assess PRS association with MINS, evaluated independently and with RCRI.

Main Results:

The study included 253 MINS cases and 253 controls of European ancestry.
Polygenic risk scores for type II diabetes (T2D PRS) and HbA1c were significantly associated with MINS.
No significant associations were found for PRS related to coronary artery disease, stroke, or lipid biomarkers.

Conclusions:

T2D PRS and HbA1c PRS are associated with an increased risk of MINS.
These findings suggest the multifactorial pathophysiology of MINS.
Further genetic studies and trials on perioperative glucose management are recommended.