Synchronous metastatic malignancy of the prostate and stomach: A case report

Gastric cancers are silent malignancies that are typically diagnosed at advanced stages. Similarly, patients with prostate cancer can have an asymptomatic presentation despite widespread metastasis. The insidious nature of both malignancies highlights the importance of implementing appropriate screening protocols for early detection, prompt treatment, and better patient outcomes.

A 66-year-old man presented with unintentional weight loss and early satiety for 3 months and was found to have gastric adenocarcinoma after diagnostic testing. Further imaging demonstrated prostate enlargement and diffuse bony involvement, culminating in the diagnosis of a second primary tumor, prostate adenocarcinoma. A workup of gastric adenocarcinoma revealed metastasis to aortic-pulmonary (level 5) lymph nodes. Gastric outlet obstruction was treated with open gastrojejunostomy. Metastatic prostate cancer was treated with hormonal therapy.

Double primary tumors are rare occurrences and patient care should be optimized using an interdisciplinary care team. Treatment aims to mitigate disease progression, and is influenced by tumor type, anatomical location, and criteria for resectability.

Both gastric and prostate cancer pose significant challenges in both diagnosis and treatment, largely due to its often-asymptomatic nature in early stages and the complexity of its progression.