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Updated: May 4, 2026

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
3rd trimester ultrasound assessment
Cecilia Villalain1, Alberto Galindo1, Enery Gómez-Montes1
1Foetal Medicine Unit. Obstetrics and Gynecology Department. Hospital Universitario 12 de Octubre. Complutense University, Madrid. Instituto de Investigación Del Hospital 12 de Octubre (imas12). Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS Network), RD21/0012/0024, Madrid, Spain.
The third-trimester scan allows not only the assessment of foetal growth but also its presentation and anatomy, and placental, amniotic fluid, and umbilical cord anomalies. Although there is a great disparity when considering its recommendation, most recent studies raise the question for its usefulness considering its impact in a potential reduction of perinatal morbidity and mortality. For this to be a reality in a population-wide setting, a systematic approach should be made considering performing it between 35 + 0 and 36 + 6 weeks', including the assessment of estimated foetal weight, foetal Doppler (umbilical and middle cerebral artery), placenta, amniotic fluid, foetal anatomy, and presentation. In high-risk cases, additional evaluation of the placenta, umbilical cord, or advanced foetal anatomy assessment can be warranted. Furthermore, pre-defined and evidence-based protocols should be followed after anomalies are detected in order to improve maternal and perinatal outcomes.
The third-trimester scan allows not only the assessment of foetal growth but also its presentation and anatomy, and placental, amniotic fluid, and umbilical cord anomalies. Although there is a great disparity when considering its recommendation, most recent studies raise the question for its usefulness considering its impact in a potential reduction of perinatal morbidity and mortality. For this to be a reality in a population-wide setting, a systematic approach should be made considering performing it between 35 + 0 and 36 + 6 weeks', including the assessment of estimated foetal weight, foetal Doppler (umbilical and middle cerebral artery), placenta, amniotic fluid, foetal anatomy, and presentation. In high-risk cases, additional evaluation of the placenta, umbilical cord, or advanced foetal anatomy assessment can be warranted. Furthermore, pre-defined and evidence-based protocols should be followed after anomalies are detected in order to improve maternal and perinatal outcomes.
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