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Updated: Jul 13, 2026

Three-Dimensional (3D) Tumor Spheroid Invasion Assay
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Published on: May 1, 2015

Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

Sarah L Breves1, Dafne Campigli Di Giammartino2, James Nicholson3

  • 1Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Physiology, Biophysics and Systems Biology Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA; Department of Surgery, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA; Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Molecular Cell
|March 27, 2025
PubMed
Summary

Dysregulated enhancer-promoter networks in the 3D nucleus drive cancer. Identifying 3D regulatory hubs in glioblastoma reveals key oncogenic programs and potential therapeutic targets across multiple cancers.

Keywords:
3D chromatin organizationCRISPRiHiChIPclonogenicityenhancer hubsenhancer-promoter interactionsglioblastomaoncogenic programregulatory hubssingle-cell RNA-seqstructural variants

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