lncRNA NR_146969 promotes the progression of lung adenocarcinoma
- Ying Chen 1, Juan Wang 1, Linguo Gu 1, Hongzuo Chen 1, Zhengling Gai 1, Rui Hu 1, Bei Qing 1, Yunchang Yuan 1, Zhenkun Xia 1
- 1Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China; Hunan Provincial Key Laboratory of Early Diagnosis and Precision Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
- 0Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China; Hunan Provincial Key Laboratory of Early Diagnosis and Precision Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
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View abstract on PubMed
Summary
This summary is machine-generated.Long non-coding RNA NR_146969 promotes lung adenocarcinoma (LUAD) growth and metastasis by targeting SLC6A14. Targeting this long non-coding RNA may offer a new therapeutic strategy for LUAD patients.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Dysregulation of long non-coding RNAs (lncRNAs) is implicated in cancer development.
- lncRNA array technology identified differentially expressed lncRNAs in lung adenocarcinoma (LUAD).
- lncRNA NR_146969 was found upregulated in LUAD and associated with metastasis and clinical stage.
Purpose Of The Study
- To investigate the clinical significance and function of candidate lncRNAs in LUAD.
- To elucidate the oncogenic role and underlying mechanism of lncRNA NR_146969 in LUAD progression.
Main Methods
- lncRNA expression profiling using array technology.
- Functional assays including CCK-8, colony formation, Transwell, and xenograft models.
- Mechanism exploration via FISH, dual luciferase reporter, and recovery assays.
Main Results
- lncRNA NR_146969 exhibits an oncogenic role in LUAD.
- NR_146969 targets SLC6A14 through miR-26a-1-3p.
- This interaction activates the AKT/mTOR pathway, promoting LUAD growth and metastasis.
Conclusions
- lncRNA NR_146969 is a key driver of LUAD progression.
- Targeting lncRNA NR_146969 presents a potential novel therapeutic strategy for LUAD.
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