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Calcium phosphate adjuvanted allergens.

E H Relyveld, M R Ickovic, E Hénocq

    Annals of Allergy
    |June 1, 1985
    PubMed
    Summary
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    Calcium phosphate shows promise as an alternative adjuvant for allergen immunotherapy, demonstrating high efficacy and good tolerance in preliminary studies. This approach may offer a safe and effective option for treating allergies.

    Area of Science:

    • Immunology
    • Allergen immunotherapy

    Background:

    • Calcium phosphate is a well-established adjuvant in vaccine development, known for high immunogenicity and safety.
    • Aluminum compounds are commonly used adjuvants for adsorbed allergens in immunotherapy.

    Purpose of the Study:

    • To evaluate calcium phosphate as an alternative adjuvant for adsorbed allergens, replacing traditional aluminum compounds.
    • To assess the efficacy and tolerance of calcium phosphate-adjuvanted allergens in immunotherapy.

    Main Methods:

    • Purified extracts of house dust, mite, and grass pollen were used to prepare adsorbed allergens with calcium phosphate.
    • Immunotherapy was administered using these preparations, and results were compared to fluid preparations and published data on aluminum-adjuvanted allergens.

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    Main Results:

    • Immunotherapy with calcium phosphate-adjuvanted house dust and mite extracts yielded a 70% satisfactory therapeutic outcome.
    • Efficacy was comparable to fluid preparations, though the latter required more injections.
    • Calcium phosphate-adjuvanted allergens demonstrated comparable efficacy to aluminum-adjuvanted allergens.

    Conclusions:

    • Calcium phosphate is a viable alternative adjuvant for allergen immunotherapy, showing high efficacy and good tolerance.
    • Further clinical evaluation is needed for grass pollen extracts after a minimum of three treatment seasons.