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Updated: Jun 28, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

The Hippo pathway: Organ size control and beyond.

Pengfei Guo¹, Sicheng Wan², Kun-Liang Guan¹

¹School of Life Sciences, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.

Pharmacological Reviews

|March 27, 2025

Summary

The Hippo signaling pathway controls organ size and tissue repair by regulating YAP/TAZ activity. Understanding its spatial organization and biomolecular condensates offers new cancer and regenerative medicine therapies.

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

The Hippo signaling pathway is a conserved regulator of organ size, tissue homeostasis, and regeneration.
It integrates diverse signals to control YAP/TAZ transcriptional coactivators.
Pathway regulation involves spatial organization at the plasma membrane and biomolecular condensation.

Purpose of the Study:

To review the regulatory mechanisms of the Hippo signaling pathway.
To highlight the role of spatial organization and biomolecular condensation in Hippo signaling.
To discuss the implications of Hippo pathway dysregulation in cancer and regenerative medicine.

Main Methods:

Literature review of recent studies on the Hippo signaling pathway.
Analysis of molecular mechanisms controlling pathway activity.
Discussion of therapeutic strategies targeting the Hippo pathway.

Main Results:

The Hippo pathway's spatial organization at the plasma membrane is critical for its precise control.
Biomolecular condensation adds complexity to Hippo signaling regulation.
Dysregulation of the Hippo pathway, particularly YAP/TAZ activity, is linked to cancer and impacts drug resistance.

Conclusions:

Understanding Hippo pathway regulation provides insights into organ size control and tissue repair.
Targeting the Hippo pathway offers therapeutic potential for cancer treatment and regenerative medicine.
Small molecule inhibitors targeting YAP-TEAD interactions represent a promising therapeutic avenue.