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Related Experiment Videos

Neuroglia in suicide.

Lin Zhang1, Dick F Swaab1

  • 1Neuropsychiatric Disorders Lab, Neuroimmunology Group, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Handbook of Clinical Neurology
|March 27, 2025
PubMed
Summary

Neuroglia, or brain cells, play a role in suicide neuropathology. Understanding their function may lead to new suicide prevention therapies and biomarkers.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cell Biology

Background:

  • Suicide is a major outcome of neuropsychiatric disorders, incurring significant social and economic costs.
  • Understanding the neurobiology of suicide and resilience is crucial for developing effective treatments.
  • The role of neuroglia in suicide neuropathology, versus secondary changes in comorbid disorders, remains debated.

Purpose of the Study:

  • To review existing literature on the involvement of neuroglia in suicide.
  • To explore how neuroglia respond to current pharmacological interventions for suicidal behavior.
  • To elucidate the neurobiological mechanisms underlying neuroglial contributions to suicide.

Main Methods:

  • Literature review of studies investigating neuroglia and suicide.
Keywords:
AstrogliaMicrogliaNeuropsychiatric disordersOligodendrogliaPostmortem human brainSuicide

Related Experiment Videos

  • Analysis of neuroglial biological features in relation to suicide and psychiatric disorders.
  • Examination of molecular commonalities and morphologic changes in neuroglia across different psychiatric conditions.

    • Main Results:

    • Neuroglia exhibit distinct biological features relevant to suicide and associated psychiatric disorders.
    • Shared molecular alterations in neuroglia are observed across various psychiatric disorders linked to suicide.
    • Evidence suggests morphologic changes in neuroglia correlate with suicide severity and resilience.

    Conclusions:

    • Neuroglia are actively involved in the neuropathology of suicide.
    • Further research into neuroglial mechanisms can identify suicide biomarkers.
    • Targeting neuroglia may offer novel therapeutic strategies for suicide prevention.