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Published on: August 25, 2015
Pathophysiology of Laryngopharyngeal Reflux Disease: The Reflux vs Reflex Theory
Edoardo Vincenzo Savarino1, Jérôme René Lechien2, Luisa Bertin3
1Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Gastroenterology Unit, Azienda Ospedale Università Padova, Padua, Italy.
Abstract:
Laryngopharyngeal reflux (LPR) involves the reflux of stomach contents into the upper aerodigestive tract, causing symptoms through both direct injury and reflex-mediated mechanisms. While traditional reflux and reflex theories provide insights into LPR pathogenesis, they do not fully encompass its clinical spectrum. Emerging evidence highlights the role of hypersensitivity-both peripheral and central-in LPR, with significant implications for treatment responses and the impact of psychological factors on symptom severity. Understanding these complex interactions is crucial for developing more effective management strategies for LPR.
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