CRNDE, a Potential Therapeutic Target in Human Diseases
Shiyun Zeng1,2, Yao Xie1,3, Yulan Shi1,3
1Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
Current Pharmaceutical Design
|March 28, 2025
Summary
Colorectal tumor Differentially Expressed (CRNDE) is a long non-coding RNA (lncRNA) implicated in both cancer and non-cancerous diseases. Its modulation impacts patient survival and aids in disease diagnosis, highlighting its therapeutic potential.
Area of Science:
- Molecular Biology
- Genomics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in biological processes, challenging traditional views of non-coding RNA functions.
- Colorectal tumor Differentially Expressed (CRNDE) is an oncogenic lncRNA with significant implications in various diseases.
Purpose of the Study:
- To review the expression patterns of CRNDE in human diseases, encompassing both cancerous and non-cancerous conditions.
- To elucidate CRNDE's role in disease progression and underlying molecular mechanisms.
- To explore recent therapeutic strategies targeting CRNDE.
Main Methods:
- Literature review of studies investigating CRNDE expression and function in human diseases.
- Analysis of CRNDE's impact on disease progression and patient outcomes.
- Examination of CRNDE's diagnostic and therapeutic potential.
Main Results:
- CRNDE expression is deregulated in various cancers, with modulation significantly improving patient survival (e.g., from 19.2 to 32.5 months).
- CRNDE also shows altered expression in non-malignant diseases like COVID-19, where it serves as a diagnostic indicator with high accuracy (0.889).
Conclusions:
- CRNDE is a versatile molecule with significant roles in both oncogenesis and non-cancerous pathologies.
- CRNDE holds promise as a potential biomarker for diagnosis and a therapeutic target for diverse human diseases.
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