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A retrospective study of 17,995 patients investigating the location and recurrence of papillary thyroid cancer.

Peng Qi1, Ziming Wang1, Xu Hao1

  • 1Thyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Jilin University, No. 1 Xinmin Street, Changchun City, 130021, Jilin Province, China.

Scientific Reports
|March 28, 2025
PubMed
Summary

Papillary thyroid cancer (PTC) recurrence is linked to tumor location. Tumors in the upper coronal and dorsal sagittal planes, along with lymph node metastasis and multifocality, increase recurrence risk.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Epidemiology

Background:

  • Papillary thyroid cancer (PTC) incidence is rising globally.
  • While generally having a good prognosis, advanced or metastatic PTC can recur.
  • The impact of tumor location on PTC recurrence remains poorly understood.

Purpose of the Study:

  • To investigate the correlation between the specific location of papillary thyroid cancer within the thyroid gland and its recurrence.
  • To identify anatomical locations within the thyroid associated with a higher risk of PTC recurrence.

Main Methods:

  • Retrospective analysis of 17,995 patients undergoing thyroid surgery between 2009 and 2022.
  • Tumor location precisely mapped using ultrasound and pathology reports, dividing lateral lobes into coronal (upper, middle, lower) and sagittal (anterior, dorsal) planes.
  • Kaplan-Meier analysis and Cox proportional hazards regression models employed to assess recurrence and risk factors.

Main Results:

  • The upper part of the coronal plane and the dorsal part of the sagittal plane showed the strongest association with PTC recurrence.
  • Multifactorial analysis confirmed that lymph node metastatic status, tumor multifocality, and superior/dorsal tumor location were significant predictors of recurrence.

Conclusions:

  • Specific anatomical locations within the thyroid gland, particularly the superior and dorsal regions, are significantly associated with an increased risk of papillary thyroid cancer recurrence.
  • Tumor location, in conjunction with lymph node status and multifocality, should be considered in risk stratification and management of PTC patients to predict and potentially mitigate recurrence.