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Sleep and Cancer.

Courtney M Vaughn1, Bradley V Vaughn2

  • 1Department of Pediatrics, Division of Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cancers
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

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RETRACTED: Sabir et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. <i>Cancers</i> 2021, <i>13</i>, 3396.

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Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

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Sleep problems are common in cancer patients and can affect cancer progression. Treating sleep disorders may improve cancer patients

Area of Science:

  • Oncology
  • Sleep Medicine
  • Molecular Biology

Background:

  • Sleep disturbances are prevalent in the general population and significantly more common in cancer patients.
  • Sleep problems may precede cancer diagnosis, prompting interest in sleep's role in cancer development and progression.
  • Sleep disorders can influence cancer through metabolic, immune, hormonal, and gene expression pathways.

Purpose of the Study:

  • To review the complex relationship between sleep and cancer.
  • To elucidate the underlying mechanisms connecting sleep and cancer.
  • To outline treatment methods and impacts for sleep issues in cancer patients and provide a clinical approach.

Main Methods:

  • A comprehensive literature search was conducted using the National Library of Medicine.
Keywords:
cancerexcessive sleepinessinsomniasleepsleep disorderssleep disruption

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  • Studies were selected based on their examination of the sleep-cancer relationship.
  • Characterization of selected studies provided specific information on the sleep-cancer connection.
  • Main Results:

    • The review summarizes current understanding of the sleep-cancer interrelationship.
    • Mechanisms linking sleep and cancer, including metabolic, immune, and hormonal factors, are discussed.
    • Treatment strategies for sleep disorders in cancer patients and their impact on outcomes are presented.

    Conclusions:

    • Further research is crucial to fully understand the sleep-cancer relationship.
    • The impact of sleep on cancer and vice versa is cancer-type and molecularly specific.
    • Multimodal treatment of sleep disorders offers a promising approach to enhance cancer patient health and quality of life.