Neutrophil/Lymphocyte Ratio (NLR) as a Predictive Marker for p16 Positivity and Cervical Cancer Progression: Insights from the SCOPE Study
- Zsófia Tóth 1, Lotti Lőczi 1, Barbara Sebők 2, Petra Merkely 1, Emese Keszthelyi 1, Balázs Lintner 1, Nándor Ács 1, Attila Keszthelyi 3, Szabolcs Várbíró 1,2,4, Richárd Tóth 1, Márton Keszthelyi 1
- Zsófia Tóth 1, Lotti Lőczi 1, Barbara Sebők 2
- 1Department of Obstetrics and Gynecology, Semmelweis University, 1082 Budapest, Hungary.
- 2Workgroup of Research Management, Doctoral School, Semmelweis University, 1085 Budapest, Hungary.
- 3Department of Urology, Semmelweis University, 1082 Budapest, Hungary.
- 4Department of Obstetrics and Gynecology, University of Szeged, 6725 Szeged, Hungary.
- 0Department of Obstetrics and Gynecology, Semmelweis University, 1082 Budapest, Hungary.
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View abstract on PubMed
Summary
This summary is machine-generated.Neutrophil/lymphocyte ratio (NLR) is a useful biomarker for human papillomavirus (HPV)-related cervical disease, correlating with p16 and HPV DNA positivity in cervical intraepithelial neoplasia (CIN) cases.
Area Of Science
- Gynecology
- Oncology
- Immunology
Background
- Cervical cancer is a major global health issue, often caused by persistent high-risk human papillomavirus (HPV) infections.
- Systemic inflammatory markers like neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR) may indicate disease progression.
Purpose Of The Study
- To investigate the association between systemic inflammatory markers (NLR, PLR, LMR) and p16 positivity in cervical intraepithelial neoplasia (CIN).
- To evaluate the potential of these markers as biomarkers for HPV-related cervical disease.
Main Methods
- Retrospective analysis of 395 patients undergoing LEEP conization.
- Collection of data on HPV status, p16 immunostaining, and hematological parameters.
- Statistical analysis using Mann-Whitney U and chi-square tests to assess marker-outcome relationships.
Main Results
- Elevated neutrophil/lymphocyte ratio (NLR) showed a significant association with p16 positivity (p=0.011) and HPV DNA positivity (p=0.04).
- HPV-positive individuals had a higher mean NLR (2.15) than HPV-negative individuals (1.61).
- Receiver operating characteristic (ROC) analysis indicated moderate diagnostic accuracy for NLR (AUC=0.610); PLR and LMR showed no significant associations.
Conclusions
- Neutrophil/lymphocyte ratio (NLR) serves as a valuable prognostic biomarker for HPV-related cervical disease, correlating with p16 and HPV DNA positivity.
- Findings suggest systemic inflammation, as indicated by NLR, plays a role in HPV persistence and CIN progression.
- Integrating hematological and immunohistochemical markers could improve personalized management of cervical cancer.
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