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Therapeutic Potential of Prunus Species in Gastrointestinal Oncology
Gabriela Mitea1, Irina Mihaela Iancu2, Verginica Schröder3
1Department of Pharmacology, Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania.
Background:
Gastrointestinal tract cancers represent a significant worldwide health concern, accounting for almost one-third of cancer-related deaths. The existing chemotherapy drugs used in gastrointestinal cancers are ineffective, so prognosis is poor, recurrence and metastasis rates are high, and survival time remains short, necessitating the development of novel antitumor drugs that exhibit low toxicity and less potential for the development of drug resistance. This challenge is considerable, but evidence from the past decades supports the medicinal properties and functionalities of bioactive compounds such as flavonoids and acid phenolics with anticancer activities. Our purpose was to find data on the relationship between gastrointestinal cancer and bioactive compounds from Prunus species, focusing on their molecular mechanisms of action.
Results:
Studies highlight the potential of bioactive compounds from Prunus species to modulate the cancer cell signaling pathways involved in gastrointestinal tumorigenesis.
Conclusions:
The studies reviewed suggest that polyphenols from Prunus species exhibit promising gastrointestinal anticancer activities and could represent an adjunctive therapeutic strategy in cancer treatment. Further studies are necessary to validate these compounds' therapeutic potential and their feasibility as cost-effective treatments for cancer.
Insights
Bioactive compounds from Prunus species show promise in fighting gastrointestinal cancers by targeting cancer cell pathways. These natural compounds offer a potential adjunctive therapy for cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Gastrointestinal cancers are a major global health issue, causing nearly a third of cancer deaths.
- Current chemotherapy for gastrointestinal cancers has limited efficacy, leading to poor outcomes and high recurrence rates.
- There is a critical need for novel, low-toxicity antitumor drugs with reduced resistance potential.
Purpose of the Study:
- To investigate the relationship between gastrointestinal cancer and bioactive compounds from Prunus species.
- To focus on the molecular mechanisms of action of these compounds against gastrointestinal cancer.
Main Methods:
- Literature review of studies on Prunus species and their bioactive compounds.
- Analysis of molecular mechanisms by which these compounds affect cancer cell signaling pathways.
Main Results:
- Bioactive compounds from Prunus species demonstrate the potential to modulate key signaling pathways in gastrointestinal tumorigenesis.
- Flavonoids and acid phenolics from Prunus species exhibit anticancer activities relevant to gastrointestinal cancers.
Conclusions:
- Polyphenols from Prunus species show promising gastrointestinal anticancer activities.
- These compounds could serve as an adjunctive therapeutic strategy in cancer treatment.
- Further research is needed to confirm their therapeutic potential and cost-effectiveness.
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