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Allergic Reactions02:06

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Updated: Jun 19, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

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Published on: March 3, 2023

Associations of Head and Neck Cancer with Prior Allergic Rhinitis.

Shih-Han Hung1,2,3, Tzong-Hann Yang4,5,6,7,8, Herng-Ching Lin9,10

  • 1Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Cancers
|March 28, 2025
PubMed
Summary

This study found a significant association between allergic rhinitis (AR) and an increased risk of head and neck cancer (HNC). Individuals with AR showed a higher prevalence of HNC, particularly in specific sites.

Keywords:
allergic rhinitisepidemiologyhead and neck cancersrisk factors

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Area of Science:

  • Oncology
  • Immunology
  • Epidemiology

Background:

  • Chronic inflammation is a known factor in cancer development.
  • The relationship between allergic rhinitis (AR) and head and neck cancer (HNC) requires further investigation.
  • Understanding this link can inform preventative strategies and patient risk assessment.

Purpose of the Study:

  • To investigate the potential association between a history of allergic rhinitis (AR) and the risk of developing head and neck cancer (HNC).
  • To quantify this association using a large-scale, population-based dataset.
  • To explore site-specific risks of HNC in relation to AR.

Main Methods:

  • A population-based case-control study was conducted using the Taiwan Longitudinal Health Insurance Database 2010.
  • 14,913 HNC patients were compared with 59,652 propensity-score matched controls.
  • Multivariate logistic regression analyses adjusted for demographic factors and comorbidities (e.g., diabetes, hypertension, HPV infection).

Main Results:

  • A prior diagnosis of AR was more prevalent in HNC patients (26.2%) compared to controls (18.70%).
  • The adjusted odds ratio (OR) for HNC in patients with prior AR was 1.559 (95% CI = 1.494-1.627).
  • Significantly increased ORs for AR were observed in specific HNC sites, including nasopharynx (OR=2.933), sinonasal (OR=3.100), larynx (OR=1.537), salivary glands (OR=1.470), and thyroid (OR=1.566).

Conclusions:

  • The study provides robust evidence supporting a significant link between allergic rhinitis and an elevated risk of head and neck cancer.
  • AR is associated with increased risk for specific HNC subtypes, notably nasopharyngeal, sinonasal, laryngeal, salivary gland, and thyroid cancers.
  • These findings highlight the potential role of AR in HNC pathogenesis and suggest avenues for further research and clinical consideration.