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Updated: Jun 25, 2026
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Identification and Expression Analyses of IL-17/IL-17R Gene Family in Snakehead (Channa argus) Following Nocardia
Xiufeng Han1, Xue Su1, Mingyue Che1
1School of Marine Science and Engineering, Qingdao Agricultural University, 700 Greatwall Road, Qingdao 266109, China.
Background/Objectives:
The interleukin 17 (IL-17) family, known for its proinflammatory properties, is important in immune responses against bacterial and fungal infections. To exert its immune function, the IL-17 family typically binds to IL-17 receptor (IL-17R) to facilitate signal transduction.
Methods:
This study identified, cloned and analyzed seven IL-17 and nine IL-17R family members in snakeheads.
Results:
A duplication event occurred in snakehead IL-17s and IL-17Rs, but bioinformatics analyses indicated that these genes were conserved in both protein domains and evolutionary processes. Tissue distribution analysis revealed that IL-17s/IL-17Rs were widely distributed in the detected tissues, with relatively high expression levels in immune tissues. Upon Nocardia seriolae stimulation, most members were expressed, particularly IL-17C2, IL-17D, IL-17N, IL-17RA1, IL-17RA2, IL-17RC1, and IL-17RE1, which were significantly upregulated in gill and intestine.
Conclusions:
These results suggested that IL-17s and IL-17Rs played a crucial role in mucosal immunity against bacterial infection, providing insights into immunoprophylactic strategies for bacterial diseases in aquaculture.
