Related Experiment Video

Updated: Jan 12, 2026

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.5K

The Emerging Role of MicroRNAs in Nasal Inflammatory Diseases and Tumors: From Bench to Bedside

Antonella Loperfido1, Carlo Cavaliere2, Bruno Fionda3

  • 1Otolaryngology Unit, San Camillo Forlanini Hospital, Circonvallazione Gianicolense 87, 00152 Rome, Italy.

Genes
|March 28, 2025
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are key regulators in nasal diseases like chronic rhinosinusitis (CRS) and sinonasal tumors. These molecules show promise for non-invasive diagnostics and targeted therapies, advancing personalized medicine.

Area of Science:

  • Immunology
  • Molecular Biology
  • Otorhinolaryngology

Background:

  • MicroRNAs (miRNAs) are critical regulators of immune responses.
  • miRNAs are implicated in the pathogenesis of nasal diseases, including chronic rhinosinusitis (CRS), allergic rhinitis (AR), and sinonasal tumors.

Purpose of the Study:

  • To comprehensively review the role of miRNAs in inflammatory and oncological nasal diseases.
  • To highlight the diagnostic, prognostic, and therapeutic potential of miRNAs in nasal pathologies.

Main Methods:

  • A comprehensive literature review was performed.
  • Key studies on miRNA expression, regulatory mechanisms, biomarkers, and therapeutics in nasal diseases were analyzed.

Main Results:

  • Altered miRNA expression profiles are involved in the pathogenesis of CRS, AR, and sinonasal tumors.
  • Specific miRNAs (e.g., miR-125b, miR-155) are upregulated in CRS/AR, promoting inflammation.
  • Dysregulated miRNAs (e.g., miR-126, miR-34/miR-449) impact sinonasal tumor progression and treatment response.
  • Exosome-mediated miRNA delivery presents a promising strategy for precision medicine.

Conclusions:

  • miRNAs are key regulators in nasal diseases with potential for non-invasive diagnostics and targeted therapies.
  • Further research into miRNA-based interventions can improve treatment outcomes for nasal disorders and malignancies.
  • miRNAs offer a pathway towards personalized medicine approaches for nasal conditions.
Keywords:
allergic rhinitisbiomarkerschronic rhinosinusitismiRNA therapymiRNAsmicroRNAspersonalized medicinesinonasal tumors

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