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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Chromatin Isolation by RNA Purification (ChIRP)
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LncRNAs Ride the Storm of Epigenetic Marks.

Giulia Gaggi1,2, Clinton Hausman3,4,5, Soomin Cho3,4,5

  • 1Department of Medicine and Aging Sciences, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.

Genes
|March 28, 2025
PubMed
Summary

Long non-coding RNAs (lncRNAs) are key regulators of gene expression and epigenetics. Their dysregulation contributes to genetic disorders and cancers, offering potential therapeutic targets.

Keywords:
chromatinepigenetic marksepigenetic memoryepigeneticsncRNA

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Area of Science:

  • Genomics
  • Epigenetics
  • Molecular Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their critical roles in cellular functions.
  • Dysregulation of lncRNAs is linked to various diseases, including cancer and genetic disorders.
  • lncRNAs significantly influence gene expression through epigenetic mechanisms.

Purpose of the Study:

  • To review the current understanding of lncRNA-mediated epigenetic regulation.
  • To highlight the implications of lncRNAs in cancer and genetic disease development.

Main Methods:

  • Literature review of recent advancements in lncRNA research.
  • Analysis of lncRNA's role in epigenetic modifications (DNA methylation, histone modification, chromatin remodeling).

Main Results:

  • lncRNAs are integral to gene regulatory pathways controlling cell growth and development.
  • lncRNAs modulate epigenetic landscapes, impacting gene expression.
  • Specific lncRNAs are implicated in the pathogenesis of diverse cancers and genetic conditions.

Conclusions:

  • lncRNAs are crucial epigenetic regulators with significant biomedical implications.
  • Targeting lncRNAs offers potential therapeutic strategies for cancers and genetic diseases.