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MYOSLID: A Critical Modulator of Cancer Hallmarks

Kanupriya Medhi1, Sagarika Mukherjee1, Aastha Dagar1

  • 1Non-Coding RNA and Cancer Biology Lab, Department of Zoology, Central University of Punjab, Ghudda, Bathinda 151401, Punjab, India.

Genes
|March 28, 2025
PubMed

Insights

MYOSLID, a novel long non-coding RNA, significantly impacts cancer progression by affecting proliferation, immune evasion, and metastasis. Its dysregulation in colorectal and head and neck cancers indicates poor prognosis, highlighting its potential as a biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer remains a leading global cause of death due to a lack of precise biomarkers.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in complex diseases like cancer.

Purpose of the Study:

  • To review the role and clinical significance of the lncRNA MYOSLID in cancer progression.
  • To explore MYOSLID's potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Literature review of MYOSLID's functions in cancer hallmarks.
  • Analysis of MYOSLID expression data from The Cancer Genome Atlas (TCGA) and ENCORI database.
  • Correlation analysis of MYOSLID expression with patient prognosis in colorectal adenocarcinoma (COAD) and head and neck squamous cell carcinoma (HNSCC).

Main Results:

  • MYOSLID promotes tumor growth by stabilizing hypoxia-inducible factor 1 and acting as a competing endogenous RNA (ceRNA) for tumor-suppressive microRNAs.
  • MYOSLID facilitates immune evasion by upregulating PD-L1 and modulating necroptosis pathways.
  • MYOSLID enhances metastasis by regulating epithelial-mesenchymal transition markers and promoting cytoskeletal remodeling.
  • Elevated MYOSLID expression in COAD and HNSCC correlates with poor prognosis and reduced survival rates.

Conclusions:

  • MYOSLID is a critical modulator of multiple cancer hallmarks, including proliferation, immune evasion, and metastasis.
  • MYOSLID expression levels are associated with poor clinical outcomes in specific cancer types.
  • MYOSLID presents significant potential as a diagnostic biomarker and therapeutic target for cancer treatment.
Keywords:
LncRNAMYOSLIDactivating invasion and metastasisavoiding immune destruction and cell death resistancecancer hallmarkscolorectal cancerderegulating cellular metabolismgastric cancerhead and neck squamous cell carcinomaoral cell squamous carcinomaosteosarcomasustaining proliferative signaling

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