The Prognostic Value and Immunomodulatory Role of Spsb2, a Novel Immune Checkpoint Molecule, in Hepatocellular Carcinoma
- Lv Tian 1, Yiming Wang 2, Jiexin Guan 1, Lu Zhang 1, Jun Fan 1
- Lv Tian 1, Yiming Wang 2, Jiexin Guan 1
- 1Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 611731, China.
- 2School of Nursing, Jilin University, Changchun 130021, China.
- 0Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 611731, China.
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View abstract on PubMed
Summary
This summary is machine-generated.Higher SPSB2 gene expression in liver cancer (LIHC) correlates with poorer patient outcomes and impacts immune responses. This study highlights SPSB2 as a potential prognostic biomarker for LIHC, offering new insights into cancer development.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Hepatocellular carcinoma (LIHC) is a leading cause of cancer mortality with increasing incidence.
- The gene SPSB2, known for its role in cell signaling in other cancers, lacks study in LIHC pathogenesis.
Purpose Of The Study
- To investigate the role of SPSB2 in the development and prognosis of LIHC.
- To explore the correlation between SPSB2 expression and clinical indicators, biological functions, and immune microenvironment in LIHC.
Main Methods
- Utilized TCGA, GTEx, and GEO databases for differential gene expression analysis.
- Performed COX regression, enrichment analysis, ssGSEA, and Spearman correlation.
- Validated SPSB2's biological functions in LIHC cell lines (Huh7 and SMMC-7721).
Main Results
- Elevated SPSB2 expression in LIHC patients is associated with poorer prognosis and significant clinical indicators (e.g., histologic grade, T stage, AFP level).
- SPSB2 is enriched in tumorigenesis and immune-related pathways, correlating with immune cells and checkpoints.
- SPSB2 knockdown inhibited proliferation, invasion, and metastasis in LIHC cell lines.
Conclusions
- SPSB2 plays a critical role in LIHC development, linked to immune response and adverse outcomes.
- SPSB2 may serve as a valuable clinical biomarker for predicting LIHC prognosis.
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