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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

Exploring Disparities in Atherosclerosis Comorbidity with Aortic Aneurysm

Aksana N Kucher1, Iuliia A Koroleva1, Maria S Nazarenko1

  • 1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russia.

Biomedicines
|March 28, 2025
PubMed

Insights

Aortic aneurysm and atherosclerosis comorbidity varies significantly, influenced by aneurysm location, genetic factors, and patient characteristics. Understanding these factors is key to managing these common vascular diseases.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Genetics

Background:

  • Aortic aneurysm (AA) and atherosclerosis (AS) are common, often asymptomatic vascular diseases with serious complications.
  • The comorbidity between AA and AS exhibits significant variability, impacting clinical outcomes.

Purpose of the Study:

  • To review and understand the factors influencing the direct and inverse comorbidity of AA and AS.
  • To highlight the importance of detailed characterization of influencing factors in scientific publications.

Main Methods:

  • Literature review of scientific publications on AA and AS comorbidity.
  • Analysis of factors affecting comorbidity estimates, including AA location, genetic factors, and patient demographics.
  • Consideration of cardiovascular and non-cardiovascular comorbidities.

Main Results:

  • Comorbidity estimates are influenced by AA location (e.g., abdominal vs. thoracic), familial/sporadic cases, syndromic forms, and aortic valve pathology (e.g., bicuspid aortic valve).
  • Patient characteristics (age, sex) and risk factors (hypertension, hypercholesterolemia, diabetes, smoking) are crucial.
  • Multimorbidity, including metabolic and endocrine disorders, plays a significant role.

Conclusions:

  • Accurate assessment of AA and AS comorbidity requires detailed consideration of numerous clinical, genetic, and systemic factors.
  • Further research should focus on comprehensive patient and disease characterization to elucidate comorbidity mechanisms.

Keywords:
aortic aneurysmatherosclerosiscomorbidity

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