Related Experiment Video
Updated: Jul 4, 2026
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 7, 2013
Exploring Disparities in Atherosclerosis Comorbidity with Aortic Aneurysm
Aksana N Kucher1, Iuliia A Koroleva1, Maria S Nazarenko1
1Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russia.
Biomedicines
|March 28, 2025
Summary
Aortic aneurysm and atherosclerosis comorbidity varies significantly, influenced by aneurysm location, genetic factors, and patient characteristics. Understanding these factors is key to managing these common vascular diseases.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
- Genetics
Background:
- Aortic aneurysm (AA) and atherosclerosis (AS) are common, often asymptomatic vascular diseases with serious complications.
- The comorbidity between AA and AS exhibits significant variability, impacting clinical outcomes.
Purpose of the Study:
- To review and understand the factors influencing the direct and inverse comorbidity of AA and AS.
- To highlight the importance of detailed characterization of influencing factors in scientific publications.
Main Methods:
- Literature review of scientific publications on AA and AS comorbidity.
- Analysis of factors affecting comorbidity estimates, including AA location, genetic factors, and patient demographics.
- Consideration of cardiovascular and non-cardiovascular comorbidities.
Main Results:
- Comorbidity estimates are influenced by AA location (e.g., abdominal vs. thoracic), familial/sporadic cases, syndromic forms, and aortic valve pathology (e.g., bicuspid aortic valve).
- Patient characteristics (age, sex) and risk factors (hypertension, hypercholesterolemia, diabetes, smoking) are crucial.
- Multimorbidity, including metabolic and endocrine disorders, plays a significant role.
Conclusions:
- Accurate assessment of AA and AS comorbidity requires detailed consideration of numerous clinical, genetic, and systemic factors.
- Further research should focus on comprehensive patient and disease characterization to elucidate comorbidity mechanisms.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:30Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:30Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...