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E-Cadherin Is Important in the In Vitro Postnatal Development and Function of Pig Islets

Kieran Purich1, Josue Rodriguez Silva1, Wenlong Huang1,2

  • 1Department of Surgery, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, AB T6G 2B7, Canada.

Biomedicines
|March 28, 2025
PubMed
Summary

E-cadherin plays a crucial role in pig islet development and function. Blocking E-cadherin impairs insulin secretion, highlighting its importance for potential islet transplantation therapies.

Keywords:
E-cadherinadult pig isletsglucose-stimulated insulin secretionin vitro cultureneonatal pig islets

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