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Lactylation and Central Nervous System Diseases.

Ye Chen1,2, Dongqiong Xiao1,2, Xihong Li1,2

  • 1Department of Emergency Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Brain Sciences
|March 28, 2025
PubMed
Summary

Lactate, a product of glycolysis, drives lactylation, an epigenetic process impacting cell functions and nervous system regulation. Targeting lactylation may offer new treatments for central nervous system (CNS) diseases.

Keywords:
central nervous system diseaseslactatelactylation

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Area of Science:

  • Biochemistry
  • Epigenetics
  • Neuroscience

Background:

  • Lactate, a glycolysis byproduct, functions as an energy source, metabolite, and signaling molecule.
  • Lactylation, an epigenetic modification mediated by lactate, occurs in both normal and disease states.
  • Lactylation is integral to cellular functions, macrophage polarization, and nervous system regulation.

Purpose of the Study:

  • To explore the role of lactylation in central nervous system (CNS) diseases.
  • To understand how lactate's epigenetic functions link metabolic regulation to neurological disorders.

Main Methods:

  • The study reviews existing literature on lactate metabolism and lactylation.
  • It analyzes the involvement of lactylation in various CNS conditions.
  • It discusses the enzymes and proteins associated with lactylation.

Main Results:

  • Lactylation is a key mechanism for lactate's diverse biological functions.
  • Lactylation links metabolic changes to CNS diseases like Alzheimer's and stroke.
  • The study highlights lactylation's role in traumatic brain injury, Alzheimer's disease, acute ischemic stroke, and schizophrenia.

Conclusions:

  • Lactylation is a critical epigenetic modification with significant implications for CNS health and disease.
  • Further research into lactylation enzymes and proteins is necessary.
  • Developing lactylation inhibitors or activators could provide novel therapeutic strategies for CNS disorders.