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Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal
Ilma Imtiaz1, Janet Schloss1, Andrea Bugarcic1
1National Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Military Road, Lismore, NSW 2480, Australia.
Biomolecules
|March 28, 2025
Summary
Natural compounds from eleven medicinal plants show promise in treating lung and colorectal cancers by modulating key cellular pathways. Research integrates traditional knowledge with modern science to overcome challenges like bioavailability for improved cancer therapeutics.
Area of Science:
- Integrative oncology and phytochemistry.
- Exploration of natural products for cancer therapy.
Background:
- Natural plant products have historical and ongoing significance in cancer treatment.
- Lung and colorectal cancers remain under-researched with poor prognoses.
- Limited investigation into the effects of medicinal plants on specific cancer pathways.
Purpose of the Study:
- To review lung and colorectal cancer signaling pathways modulated by bioactive compounds from eleven traditional medicinal plants.
- To identify phytoconstituents with anticancer properties and their mechanisms of action.
- To explore the integration of traditional knowledge with modern strategies for enhanced cancer therapeutics.
Main Methods:
- Literature review focusing on eleven selected traditional medicinal plants.
- Cross-referencing traditional uses with scientific literature on anticancer properties.
- Analysis of in vitro studies on phytoconstituents modulating key cancer signaling pathways (PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, TGF-β).
Main Results:
- Several isolated phytoconstituents (e.g., curcumin, baicalin, sanguinarine) demonstrate anticancer effects by modulating critical signaling pathways.
- Bioavailability challenges for compounds like curcumin and baicalin may be addressed through formulation or microbiome interactions.
- Herbal extracts from Echinacea, Glycyrrhiza, and Codonopsis are currently in clinical trials for cancer treatment.
Conclusions:
- Bioactive compounds from traditional medicinal plants offer a promising avenue for novel anticancer drug development.
- Modulation of key cancer signaling pathways and miRNA pathways by these compounds highlights their therapeutic potential.
- The synergy between traditional knowledge, scientific innovation, and technological advancements is crucial for developing effective cancer therapeutics.
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