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Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort

Thomas R Holtveg1, Anne Marie Reimer Jensen1,2, Ask Bock1

  • 1Department of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.

Biomolecules
|March 28, 2025
PubMed

Insights

High-sensitivity troponin (hsTnT) may predict peripheral artery disease (PAD) in people with HIV (PWH). Elevated hsTnT levels were linked to a higher likelihood of existing PAD and an increased risk of developing new-onset PAD over two years.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarker Research

Background:

  • People with HIV (PWH) exhibit an elevated risk for peripheral artery disease (PAD).
  • High-sensitivity troponin (hsTnT) and NT-pro B-type natriuretic peptide (NT-proBNP) are potential biomarkers for PAD in PWH.

Purpose of the Study:

  • To investigate the association between hsTnT and NT-proBNP levels and both prevalent and de novo PAD in adults with HIV.
  • To determine the predictive value of these biomarkers for PAD development in this population.

Main Methods:

  • Longitudinal study of 1011 adults with HIV, assessed at baseline and after 2 years.
  • Peripheral artery disease (PAD) was defined by ankle-brachial index (ABI) ≤ 0.9.
  • hsTnT and NT-proBNP levels were measured at baseline; ABI was assessed at baseline for prevalent PAD and at both time points for de novo PAD.

Main Results:

  • 8.7% of PWH had prevalent PAD at baseline, and 3.6% developed de novo PAD over 2 years.
  • A doubling in hsTnT concentration was associated with higher odds of prevalent PAD (OR 1.41, p=0.04) and increased risk of de novo PAD (RR 3.39, p=0.02).
  • NT-proBNP showed no significant association with prevalent or de novo PAD.

Conclusions:

  • High-sensitivity troponin (hsTnT) is associated with prevalent peripheral artery disease (PAD) in people with HIV (PWH).
  • Elevated hsTnT levels predict an increased risk of developing de novo PAD in PWH.
  • NT-proBNP is not a significant biomarker for PAD in this population.

Keywords:
HIVNT-pro B-type natriuretic peptidebiomarkerhigh-sensitivity troponin Tperipheral arterial disease

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