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Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial
Hisataka Miyai1,2,3, Takaaki Tomofuji3, Hirofumi Mizuno1,3,4
1Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Healthcare (Basel, Switzerland)
|March 28, 2025
Summary
Trehalose spray did not significantly reduce halitosis in a small study. However, it did improve oral moisture levels, suggesting it may help with oral dryness.
Area of Science:
- Oral Medicine
- Biochemistry
Background:
- Halitosis, or bad breath, is often caused by volatile sulfur compounds (VSCs) and can be linked to oral dryness.
- Trehalose is known for its ability to alleviate oral dryness.
Purpose of the Study:
- To evaluate the efficacy of trehalose in managing halitosis.
- To assess trehalose's impact on volatile sulfur compounds and oral moisture.
Main Methods:
- A prospective, double-blinded, placebo-controlled, cross-over study was conducted with 9 participants.
- Participants received either a 10% trehalose solution or a placebo spray.
- Outcomes included subjective organoleptic tests, VSC measurements, and oral moisture levels.
Main Results:
- Trehalose spray application led to a time-dependent decrease in organoleptic scores, but without statistical significance compared to placebo.
- A significant increase in oral moisture levels was observed immediately after trehalose application (p=0.047).
- No significant differences were found in volatile sulfur compound concentrations.
Conclusions:
- A single application of 10% trehalose oral spray did not demonstrate a significant effect on halitosis.
- Trehalose effectively improved oral moisture levels, indicating its potential utility for managing oral dryness.
