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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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Published on: June 8, 2015

Plant Polyphenol-Based Injectable Hydrogels: Advances and Biomedical Applications.

Renkai Zhang^1,2, Qiuyue Ma^1,3, Nannan Zheng^1,3

¹School of Medicine and Health, Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin, 150001, China.

Advanced Healthcare Materials

|March 28, 2025

Summary

Plant polyphenol hydrogels offer biocompatible and adhesive properties for biomedical uses. Further research aims to improve their stability and scalability for advanced therapies.

Keywords:

biomimetic adhesion injectable hydrogels plant polyphenols tissue engineering

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 8, 2021

Area of Science:

Biomaterials Science
Polymer Chemistry
Regenerative Medicine

Background:

Plant polyphenol-based hydrogels exhibit biocompatibility and adhesion, inspired by mussel adhesive proteins.
The catechol group facilitates stable bonding in aqueous conditions, crucial for biomedical applications.

Purpose of the Study:

To review the synthesis, adhesion mechanisms, and applications of plant polyphenol hydrogels.
To identify challenges and future research directions for clinical translation.

Main Methods:

Comprehensive literature review of plant polyphenol-based hydrogels.
Analysis of catechol group chemistry and biomimetic adhesion principles.
Evaluation of current applications in wound healing, tissue regeneration, and drug delivery.

Main Results:

Plant polyphenol hydrogels show promise in wound healing, tissue regeneration, and drug delivery.
Key challenges include in vivo stability, long-term biocompatibility, and manufacturing scalability.
AI-assisted screening and 3D/4D bioprinting are emerging technologies for development.

Conclusions:

Plant polyphenol hydrogels are a promising frontier for personalized medicine and minimally invasive treatments.
Enhancing bioactivity, biocompatibility, and scalability is crucial for clinical translation.
Integrating biomimetic designs and responsive functionalities can improve therapeutic efficacy.